Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tributyrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | PRKCA | P17252 | 4/20 | 0.62 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.62 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.54 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tributyrin SCHEMBL601928 | 0.96 | ALDH1A1 (0.72) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| Tributyrin SCHEMBL23825 | 0.96 | ALDH1A1 (0.72) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| Tributyrin SCHEMBL9694317 | 0.94 | ALDH1A1 (0.66) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| Tributyrin SCHEMBL8933438 | 0.94 | ALDH1A1 (0.70) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| Tributyrin SCHEMBL31235642 | 0.94 | ALDH1A1 (0.70) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| Tributyrin SCHEMBL29693663 | 0.94 | ALDH1A1 (0.70) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| SCHEMBL19300633 | 0.94 | ALDH1A1 (0.70) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| Tributyrin SCHEMBL8206257 | 0.94 | ALDH1A1 (0.70) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| SCHEMBL21289215 | 0.94 | ALDH1A1 (0.70) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| Tributyrin SCHEMBL28349511 | 0.94 | ALDH1A1 (0.70) | ALDH1A1LMNAPRKCAPRKCEPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113267557-B | Application of lignin as MALDI matrix in detection of small molecular substances | 浙江大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-113267557-A | Application of lignin as MALDI matrix in detection of small molecular substances | 浙江大学 | 2021-08-17 | — | — | CN | disclosed |