Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 3/20 | 0.35 |
| ▸ | KLK1 | P06870 | 2/20 | 0.35 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | ABAT | P80404 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29007663 | 0.86 | EPHX1 (0.35) | EPHX1 | |
| SCHEMBL5026454 | 0.81 | PARP10 (0.34) | KDM4ESMN1; SMN2 | |
| SCHEMBL31348907 | 0.80 | ALOX5 (0.44) | EPHX1SMN1; SMN2 | |
| SCHEMBL29156721 | 0.79 | NPSR1 (0.47) | — | |
| SCHEMBL31267216 | 0.77 | TDP1 (0.33) | — | |
| SCHEMBL5026419 | 0.73 | — | — | |
| SCHEMBL28552109 | 0.73 | MAPK1 (0.50) | SMN1; SMN2 | |
| SCHEMBL29243385 | 0.71 | ALOX5 (0.50) | KDM4E | |
| SCHEMBL28540156 | 0.71 | F11 (0.45) | F10PRSS1 | |
| SCHEMBL25339719 | 0.71 | SLC6A3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004286-A | Tricyclic compounds as plasma kallikrein inhibitors and uses thereof | 成都康弘药业集团股份有限公司 | 2021-06-22 | — | — | CN | disclosed |