Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.56 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.56 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.56 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.56 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2325526 | 0.86 | MAPT (0.76) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2860237 | 0.80 | MAPT (0.56) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2856215 | 0.78 | MAPT (0.66) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL8140350 | 0.78 | MAPT (0.71) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2321873 | 0.77 | MAPT (0.55) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL10365015 | 0.77 | TRPC3 (0.70) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL21419596 | 0.76 | TRPC1 (0.68) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL13513682 | 0.76 | MAPT (0.57) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL24303060 | 0.76 | MAPT (0.62) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL1194642 | 0.75 | TRPC1 (0.67) | MAPTTRPC3TRPC1STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |