Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.50 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.50 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.50 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.50 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | GPR6 | P46095 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2325526 | 0.82 | MAPT (0.76) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2854414 | 0.81 | MAPT (0.53) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2860236 | 0.80 | MAPT (0.62) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL10366449 | 0.80 | MAPT (0.53) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL10366507 | 0.79 | MAPT (0.50) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2857725 | 0.79 | MAPT (0.52) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2854321 | 0.79 | MAPT (0.53) | MAPTGPR6KMT2AALDH1A1MEN1 | |
| SCHEMBL2859264 | 0.78 | MAPT (0.46) | MAPTTRPC3ACHEGPR6KMT2A | |
| SCHEMBL2862087 | 0.78 | MAPT (0.51) | MAPTTRPC3ACHEGPR6KMT2A | |
| SCHEMBL2852994 | 0.76 | ALDH1A1 (0.56) | MAPTTRPC3ACHEGPR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |