Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.48 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.48 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2325308 | 0.91 | TRPC3 (0.47) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2325987 | 0.89 | ALDH1A1 (0.58) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2321864 | 0.84 | MAPT (0.52) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2325526 | 0.81 | MAPT (0.76) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2322523 | 0.80 | MET (0.37) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2322544 | 0.78 | TRPA1 (0.39) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2860236 | 0.77 | MAPT (0.62) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2327207 | 0.77 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL10366449 | 0.77 | MAPT (0.53) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL10365015 | 0.77 | TRPC3 (0.70) | MAPTTRPC3TRPC1STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904455-B1 | PYRIDAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-17 | — | — | EP | disclosed |
| US-7678795-B2 | Pyridazines as 11b-HSD1 inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| EP-1904455-A2 | PYRIDAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007003521-A2 | PYRIDAZINE DERIVATIVES AS 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-11 | — | — | WO | disclosed |
| US-20070010519-A1 | New pyridazines as 11B-HSD1 inhibitors | HOFFMANN-LA ROCHE INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010519-A1 | New pyridazines as 11B-HSD1 inhibitors | HSD11B1, HSD17B1, HSD17B11 | MAPT 2099/4885TRPC3 4579/4885TRPC1 4047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.