Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18399060 | 1.00 | RXRA (0.40) | RXRARXRBRXRGSPRGPR119 | |
| SCHEMBL22873493 | 1.00 | RXRA (0.40) | RXRARXRBRXRGSPRGPR119 | |
| SCHEMBL18398983 | 0.94 | LRRK2 (0.40) | RXRARXRBRXRGGPR119LRRK2 | |
| SCHEMBL28610255 | 0.94 | LRRK2 (0.40) | RXRARXRBRXRGGPR119LRRK2 | |
| SCHEMBL20437352 | 0.94 | LRRK2 (0.40) | RXRARXRBRXRGGPR119LRRK2 | |
| SCHEMBL21797025 | 0.91 | RXRA (0.40) | RXRARXRBRXRGSPRGPR119 | |
| SCHEMBL21797023 | 0.91 | RXRA (0.40) | RXRARXRBRXRGSPRGPR119 | |
| SCHEMBL21796750 | 0.87 | RXRA (0.46) | RXRARXRBRXRGLRRK2CYP4F2 | |
| SCHEMBL22723340 | 0.86 | GPR119 (0.40) | RXRARXRBRXRGGPR119KRAS | |
| SCHEMBL22873547 | 0.86 | GPR119 (0.40) | RXRARXRBRXRGGPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137510-B | Compound (I) | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-07-20 | — | — | CN | disclosed |