Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 8/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | SLC8A1 | P32418 | 9/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285760 | 0.94 | SLC8A1 (0.41) | GABRA5SLC8A1L3MBTL1 | |
| SCHEMBL285759 | 0.86 | GABRA5 (0.41) | GABRA5GABRA1L3MBTL1 | |
| SCHEMBL286095 | 0.85 | GABRA5 (0.43) | GABRA5GABRA1L3MBTL1 | |
| SCHEMBL2749182 | 0.85 | GAA (0.40) | GABRA5SLC8A1L3MBTL1 | |
| SCHEMBL7799568 | 0.79 | SMPD1 (0.47) | GABRA5GABRA1 | |
| SCHEMBL286247 | 0.79 | GABRA5 (0.66) | GABRA5GABRA1 | |
| SCHEMBL285941 | 0.79 | GABRA5 (0.66) | GABRA5GABRA1 | |
| SCHEMBL286228 | 0.79 | ALDH1A1 (0.36) | GABRA5L3MBTL1 | |
| SCHEMBL286096 | 0.78 | KMT2A (0.39) | GABRA5L3MBTL1 | |
| SCHEMBL286245 | 0.78 | POLB (0.40) | SLC8A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | claimed |
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |