Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2673317 | 0.94 | POLB (0.52) | SMPD1GABRA5POLBAKR1C3ALDH1A1 | |
| SCHEMBL2673312 | 0.85 | SMPD1 (0.48) | SMPD1GABRA5GABRA1 | |
| SCHEMBL15252421 | 0.85 | ALDH1A1 (0.41) | SMPD1GABRA5GABRA1ALDH1A1 | |
| SCHEMBL2673022 | 0.84 | SMPD1 (0.47) | SMPD1GABRA5POLBGABRA1AKR1C3 | |
| SCHEMBL286340 | 0.84 | GABRA5 (0.44) | GABRA5GABRA1 | |
| SCHEMBL7802104 | 0.84 | GABRA5 (0.47) | SMPD1GABRA5GABRA1 | |
| SCHEMBL7791584 | 0.84 | GABRA5 (0.47) | SMPD1GABRA5GABRA1 | |
| SCHEMBL7791577 | 0.84 | GABRA5 (0.47) | SMPD1GABRA5GABRA1 | |
| SCHEMBL2672537 | 0.84 | SMPD1 (0.46) | SMPD1GABRA5ALDH1A1 | |
| SCHEMBL2672703 | 0.84 | SMPD1 (0.44) | SMPD1GABRA5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398782-B1 | ISOXAZOLE-ISOXAZOLE AND ISOXAZOLE-ISOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-8173652-B2 | Isoxazole-isoxazoles and isoxazole-isothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173652-B2 | Isoxazole-isoxazoles and isoxazole-isothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-05-08 | — | — | US | disclosed |
| WO-2010094669-A1 | ISOXAZOLE-ISOXAZOLE AND ISOXAZOLE-ISOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-26 | — | — | WO | disclosed |
| US-20100210651-A1 | ISOXAZOLE-ISOXAZOLES AND ISOXAZOLE-ISOTHIAZOLES | ROCHE PALO ALTO LLC | 2010-08-19 | — | — | US | disclosed |
| US-20100210651-A1 | ISOXAZOLE-ISOXAZOLES AND ISOXAZOLE-ISOTHIAZOLES | ROCHE PALO ALTO LLC | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210651-A1 | ISOXAZOLE-ISOXAZOLES AND ISOXAZOLE-ISOTHIAZOLES | GABRA5, GABRA1, GABRA4 | SMPD1 4587/4885GABRA5 1/4885POLB 4135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.