Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.54 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 2/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20214 | 0.91 | PDE3B (0.66) | NPC1ALDH1A1PDE3BPDE3ASRC | |
| SCHEMBL31040124 | 0.91 | PDE3B (0.66) | NPC1ALDH1A1PDE3BPDE3ASRC | |
| SCHEMBL155069 | 0.83 | PDE3B (0.62) | PDE3BPDE3ASRCGRIA1CACNG8 | |
| Trifluoroacetic Acid SCHEMBL29921460 | 0.82 | PDE3B (0.52) | NPC1ALDH1A1PDE3BPDE3ASRC | |
| SCHEMBL11089929 | 0.80 | EIF2AK2 (0.63) | PDE3BPDE3AGRIA1CACNG8PGR | |
| SCHEMBL3132725 | 0.79 | PGR (0.73) | PDE3BPDE3AGRIA1CACNG8PGR | |
| SCHEMBL4406856 | 0.78 | CRBN (0.57) | NPC1ALDH1A1PDE3BPDE3ASRC | |
| SCHEMBL1897771 | 0.78 | TDP2 (0.75) | ALDH1A1PDE3BPDE3ASRCGRIA1 | |
| SCHEMBL153506 | 0.78 | EIF2AK2 (0.74) | NPC1ALDH1A1PDE3BPDE3ASRC | |
| SCHEMBL11534726 | 0.76 | MAPT (0.53) | ALDH1A1PDE3BPDE3ASRCGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918277-B1 | Azulene compounds | IND TECH RES INST (TW) | 2015-06-10 | — | — | EP | disclosed |
| US-7714146-B2 | Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2010-05-11 | — | — | US | disclosed |
| US-20080125590-A1 | Azulene compounds | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2008-05-29 | — | — | US | disclosed |
| EP-1918277-A2 | Azulene compounds | Industrial Technology Research Institute (TW) | 2008-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125590-A1 | Azulene compounds | AZI2, PRMT5, BRCA1 | NPC1 1869/4885ALDH1A1 421/4885PDE3B 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.