Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285882 | 0.86 | KDM4E (0.43) | KDM4ELMNAPTGS2GABRA5BACE1 | |
| SCHEMBL285881 | 0.86 | KDM4E (0.43) | KDM4ELMNAPTGS2GABRA5BACE1 | |
| SCHEMBL286207 | 0.86 | LMNA (0.46) | KDM4ELMNAPTGS2GABRA5POLB | |
| SCHEMBL286206 | 0.86 | LMNA (0.46) | KDM4ELMNAPTGS2GABRA5POLB | |
| SCHEMBL286004 | 0.83 | GABRA5 (0.46) | KDM4ELMNAPTGS2GABRA5BACE1 | |
| SCHEMBL286002 | 0.83 | GABRA5 (0.46) | KDM4ELMNAPTGS2GABRA5BACE1 | |
| SCHEMBL286110 | 0.82 | ALPL (0.48) | KDM4ELMNAPTGS2GABRA5BACE1 | |
| SCHEMBL286109 | 0.82 | ALPL (0.48) | KDM4ELMNAPTGS2GABRA5BACE1 | |
| SCHEMBL286155 | 0.81 | LMNA (0.36) | LMNAPTGS2GABRA5BACE1KMT2A | |
| SCHEMBL286088 | 0.79 | GABRA5 (0.54) | KDM4EGABRA5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |