Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285938 | 0.86 | ALDH1A1 (0.48) | POLBALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL285937 | 0.86 | ALDH1A1 (0.48) | POLBALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL286040 | 0.83 | SMN1; SMN2 (0.49) | POLBALDH1A1MEN1GAAKMT2A | |
| SCHEMBL286041 | 0.83 | SMN1; SMN2 (0.49) | POLBALDH1A1MEN1GAAKMT2A | |
| SCHEMBL286104 | 0.83 | POLB (0.44) | POLBALOX15TSHRMAPK1ALDH1A1 | |
| SCHEMBL286453 | 0.79 | GABRA5 (0.53) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL286451 | 0.79 | GABRA5 (0.53) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL285784 | 0.78 | TSHR (0.35) | POLBTSHRMAPK1ALDH1A1HSD17B10 | |
| SCHEMBL286452 | 0.78 | HPGD (0.46) | ALDH1A1MEN1GAAKMT2AMAPT | |
| SCHEMBL286182 | 0.78 | GABRA5 (0.46) | ALDH1A1MEN1GAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |