Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.34 |
| ▸ | TUBB | P07437 | 5/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861498 | 0.88 | FYN (0.36) | ADORA1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2860787 | 0.80 | ADORA1 (0.39) | ADORA1PTGER1KDM4ECSNK1EADORA2A | |
| SCHEMBL2864250 | 0.79 | KDM4E (0.38) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL27536115 | 0.78 | ALDH1A1 (0.41) | NPC1RAB9APTGER1KDM4EALDH1A1 | |
| SCHEMBL2867613 | 0.77 | ADORA2A (0.39) | ADORA1PTGER1KDM4EALDH1A1CSNK1E | |
| SCHEMBL2860785 | 0.76 | CSNK1E (0.40) | ADORA1PTGER1CSNK1EADORA2A | |
| SCHEMBL2865256 | 0.74 | PTGER1 (0.41) | ADORA1PTGER1KDM4EALDH1A1CSNK1E | |
| SCHEMBL4147011 | 0.73 | JAK2 (0.41) | ADORA1PTGER1ALDH1A1LMNACSNK1E | |
| SCHEMBL2858902 | 0.73 | ADORA2A (0.38) | ADORA1FYNPTGER1F2RL3KDM4E | |
| SCHEMBL8886702 | 0.73 | ADORA2A (0.40) | ADORA1PTGER1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776890-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-17 | — | — | US | disclosed |
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-20090203691-A1 | Novel 1H-indazole compounds | OINUMA HITOSHI | 2009-08-13 | — | — | US | disclosed |
| US-7541376-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-6982274-B2 | 1H-indazole compound | EISAI CO., LTD. (JP) | 2006-01-03 | — | — | US | disclosed |
| US-20050282880-A1 | Novel 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
| US-20040127538-A1 | Novel 1h-indazole compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-07-01 | — | — | US | disclosed |
| EP-1380576-A1 | NOVEL 1H-INDAZOLE COMPOUND | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203691-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | ADORA1 1820/4885TUBB4A 1935/4885TUBB 1609/4885 |
| US-20040127538-A1 | Novel 1h-indazole compound | MAPK1, MAPK14, MAPK3 | ADORA1 2921/4885TUBB4A 2041/4885TUBB 1718/4885 |
| US-20050282880-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | ADORA1 1820/4885TUBB4A 1935/4885TUBB 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.