Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA5A | P35218 | 2/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL11075497 | 0.85 | CYP1A2 (0.39) | CYP1A2TSHRNFKB1MAOAMAOB | |
| Pimagedine SCHEMBL5537219 | 0.85 | CYP1A2 (0.39) | CYP1A2TSHRNFKB1MAOAMAOB | |
| Pimagedine SCHEMBL11075753 | 0.85 | CYP1A2 (0.39) | CYP1A2TSHRNFKB1MAOAMAOB | |
| Phosphoric Acid SCHEMBL28602129 | 0.82 | SLC34A1 (0.44) | SLC34A1LMNACA1CA4CA5A | |
| Phosphoric Acid SCHEMBL9442053 | 0.76 | SLC34A1 (0.44) | SLC34A1LMNACA1CA4CA5A | |
| Phosphoric Acid SCHEMBL11663055 | 0.76 | SLC34A1 (0.44) | SLC34A1LMNACA1CA4CA5A | |
| Phosphoric Acid SCHEMBL2404057 | 0.76 | — | — | |
| Pimagedine SCHEMBL7763659 | 0.74 | ALDH1A1 (0.43) | CYP1A2TSHRNFKB1MAOAMAOB | |
| Pimagedine SCHEMBL27366958 | 0.74 | ALDH1A1 (0.43) | CYP1A2TSHRNFKB1MAOAMAOB | |
| Pimagedine SCHEMBL15307 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104981473-B | Azine metal phosphates as flame-retardant materials | J.M.休伯有限公司 | 2021-06-29 | — | — | CN | disclosed |