Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NCS1 | P62166 | 1/20 | 0.43 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29891538 | 1.00 | TRPV1 (0.54) | TRPV1TLR8KDM4EHPGDEPHX2 | |
| SCHEMBL28607984 | 0.85 | NPC1 (0.54) | KDM4EEPHX2GAALMNANPC1 | |
| SCHEMBL28919431 | 0.83 | KCNMA1 (0.53) | TRPV1HPGDMEN1KMT2ATDP1 | |
| SCHEMBL29891484 | 0.82 | MEN1 (0.51) | KDM4EGAAMEN1KMT2ATDP1 | |
| SCHEMBL28597946 | 0.82 | MEN1 (0.51) | KDM4EGAAMEN1KMT2ATDP1 | |
| SCHEMBL28602173 | 0.79 | CYP1A2 (0.46) | TRPV1EPHX2MEN1KMT2ALMNA | |
| SCHEMBL29891549 | 0.79 | CYP1A2 (0.46) | TRPV1EPHX2MEN1KMT2ALMNA | |
| SCHEMBL28597952 | 0.78 | LMNA (0.50) | GAAMEN1KMT2ATDP1LMNA | |
| SCHEMBL29891336 | 0.78 | LMNA (0.50) | GAAMEN1KMT2ATDP1LMNA | |
| SCHEMBL29891729 | 0.76 | KCNMA1 (0.53) | TRPV1HPGDMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113200938-B | Benzisothiazole hypoxia inducible factor 2 agonist compound or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113200938-A | Benzisothiazole hypoxia inducible factor 2 agonist compound or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2021-08-03 | — | — | CN | disclosed |