Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28602172 | 1.00 | KCNMA1 (0.53) | KCNMA1SMN1; SMN2TDP1MAPTTP53 | |
| SCHEMBL28919431 | 0.90 | KCNMA1 (0.53) | KCNMA1SMN1; SMN2TDP1MAPTTP53 | |
| SCHEMBL28597952 | 0.88 | LMNA (0.50) | SMN1; SMN2TDP1MAPTTP53RAB9A | |
| SCHEMBL29891336 | 0.88 | LMNA (0.50) | SMN1; SMN2TDP1MAPTTP53RAB9A | |
| SCHEMBL28614754 | 0.85 | THRB (0.52) | SMN1; SMN2TDP1MAPTTP53RAB9A | |
| SCHEMBL29891295 | 0.85 | THRB (0.52) | SMN1; SMN2TDP1MAPTTP53RAB9A | |
| SCHEMBL29891484 | 0.84 | MEN1 (0.51) | SMN1; SMN2TDP1MAPTTP53RAB9A | |
| SCHEMBL28597946 | 0.84 | MEN1 (0.51) | SMN1; SMN2TDP1MAPTTP53RAB9A | |
| SCHEMBL29891538 | 0.76 | TRPV1 (0.54) | SMN1; SMN2TDP1RAB9ALMNAKMT2A | |
| SCHEMBL28613320 | 0.76 | TRPV1 (0.54) | SMN1; SMN2TDP1RAB9ALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022242462-A1 | BENZOISOTHIAZOLE HYPOXIA-INDUCIBLE FACTOR-2 AGONIST COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT, PREPARATION METHOD AND APPLICATION THEREOF | 中国药科大学 | 2022-11-24 | — | — | WO | disclosed |
| CN-113200938-B | Benzisothiazole hypoxia inducible factor 2 agonist compound or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |