Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | HTR6 | P50406 | 6/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488722 | 0.86 | RAPGEF4 (0.60) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL1780727 | 0.86 | RAPGEF4 (0.74) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL27819639 | 0.85 | RAPGEF4 (0.58) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL1778140 | 0.82 | HDAC1 (0.60) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL8116244 | 0.82 | PPARG (0.61) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL1894102 | 0.81 | HTR6 (0.61) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL8121419 | 0.81 | PPARG (0.57) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL23782397 | 0.78 | PPARG (0.56) | RAPGEF4PPARGHDAC1HDAC6HTR6 | |
| SCHEMBL21805820 | 0.77 | HTR6 (0.46) | HDAC1HDAC6HTR6HDAC2USP2 | |
| SCHEMBL30088185 | 0.77 | HTR6 (0.46) | HDAC1HDAC6HTR6HDAC2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113015526-A | Spirocyclic 2, 3-dihydro-7-azaindole compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |