Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.61 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 7/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780727 | 0.86 | RAPGEF4 (0.74) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL20488722 | 0.86 | RAPGEF4 (0.60) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL23782397 | 0.85 | PPARG (0.56) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL27819639 | 0.85 | RAPGEF4 (0.58) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL28614178 | 0.82 | RAPGEF4 (0.56) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL1778140 | 0.82 | HDAC1 (0.60) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL17049351 | 0.82 | PPARG (0.53) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL1894102 | 0.81 | HTR6 (0.61) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL8121419 | 0.81 | PPARG (0.57) | PPARGRAPGEF4HTR6HDAC1HDAC6 | |
| SCHEMBL23782491 | 0.78 | PPARG (0.55) | PPARGRAPGEF4HTR6HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015444-A1 | NOVEL PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION, LTD. (KR) | 2000-07-05 | — | — | EP | disclosed |
| EP-0554247-B1 | NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES | PFIZER (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998043968-A1 | NOVEL PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 1998-10-08 | — | — | WO | disclosed |
| CN-1037439-C | Neuroprotective indolone and related derivatives | PFIZER (US) | 1998-02-18 | — | — | CN | disclosed |
| US-5498610-A | Neuroprotective indolone and related derivatives | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| US-5306723-A | Neuroprotective indolone and related derivatives | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| EP-0554247-A1 | NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES | PFIZER INC. (US) | 1993-08-11 | — | — | EP | disclosed |
| CN-1056497-A | Indolone and relevant derivative with neuroprotective | PFIZER (US) | 1991-11-27 | — | — | CN | disclosed |
| WO-1991017156-A1 | NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES | PFIZER INC (US) | 1991-11-14 | — | — | WO | disclosed |