SCHEMBL28614337

SCHEMBL28614337

N#CC(Cl)(c1ccccc1)c1ccccc1Cl.[Pd]

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 3/20 0.48
TSHR P16473 3/20 0.41
KCNA3 P22001 2/20 0.38
DRD2 P14416 3/20 0.37
DRD4 P21917 3/20 0.37
OPRM1 P35372 3/20 0.37
DRD3 P35462 3/20 0.37
CYP3A4 P08684 3/20 0.37
CYP2D6 P10635 3/20 0.37
CYP19A1 P11511 3/20 0.37
HTR2A P28223 2/20 0.37
HTR2C P28335 2/20 0.37
OPRK1 P41145 2/20 0.37
KCNH2 Q12809 2/20 0.37
LMNA P02545 2/20 0.37
CYP1A2 P05177 2/20 0.37
ADRA1A P35348 1/20 0.37
MEN1 O00255 1/20 0.37
SLC22A1 O15245 1/20 0.37
NR1I2 O75469 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11143559 0.80 TSHR (0.50) KCNN4TSHRKCNA3DRD2DRD4
SCHEMBL2392141 0.79 KCNN4 (0.53) KCNN4TSHRKCNA3DRD2DRD4
SCHEMBL11487418 0.75 KIF11 (0.42) TSHRCYP19A1CYP1A2MEN1GLA
SCHEMBL27536834 0.74 NOTUM (0.39) MAPTAR
Hydrochloric Acid SCHEMBL27736129 0.73 KIF11 (0.41) TSHRCYP19A1CYP1A2MEN1GLA
SCHEMBL6337202 0.71 KCNN4 (0.59) KCNN4TSHRKCNA3DRD2DRD4
SCHEMBL11654993 0.71 KCNN4 (0.59) KCNN4TSHRKCNA3DRD2DRD4
SCHEMBL3239466 0.71 KCNN4 (0.59) KCNN4TSHRKCNA3DRD2DRD4
SCHEMBL29354141 0.71 KCNN4 (0.59) KCNN4TSHRKCNA3DRD2DRD4
SCHEMBL26214 0.71 KCNN4 (0.59) KCNN4TSHRKCNA3DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113292593-B Alcohol derivative-oriented aromatic ring remote hydrocarbon activation method 广东工业大学 2023-01-31 CN disclosed
CN-113292593-A Alcohol derivative-oriented aromatic ring remote hydrocarbon activation method 广东工业大学 2021-08-24 CN disclosed