Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28617694 | 0.91 | HDAC1 (0.53) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL28603643 | 0.87 | KDM4E (0.44) | ACHENR2E1 | |
| SCHEMBL14476893 | 0.83 | ACHE (0.59) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL4725539 | 0.82 | KMT2A (0.49) | NR2E1 | |
| SCHEMBL28618175 | 0.78 | KDM4E (0.47) | ACHE | |
| SCHEMBL28617480 | 0.76 | KMT2A (0.73) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL14476888 | 0.75 | ACHE (0.65) | HDAC1HDAC6HDAC8ACHE | |
| SCHEMBL28614964 | 0.74 | HDAC6 (0.78) | HDAC1HDAC6 | |
| SCHEMBL24479988 | 0.73 | NPSR1 (0.47) | NR2E1 | |
| SCHEMBL5956886 | 0.73 | HDAC1 (0.66) | HDAC1HDAC6HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121527-A | Tricyclic compound and use thereof | 上海辉启生物医药科技有限公司 | 2021-07-16 | — | — | CN | disclosed |