Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286635 | 0.87 | LMNA (0.46) | LMNAPTGS2GABRA5BACE1MAPT | |
| SCHEMBL286636 | 0.87 | LMNA (0.46) | LMNAPTGS2GABRA5BACE1MAPT | |
| SCHEMBL286546 | 0.86 | PTGS2 (0.41) | LMNAKMT2ARETPTGS2GABRA5 | |
| SCHEMBL286212 | 0.86 | PTGS2 (0.41) | LMNAKMT2ARETPTGS2GABRA5 | |
| SCHEMBL286288 | 0.83 | GABRA5 (0.45) | GABRA5 | |
| SCHEMBL285913 | 0.83 | GABRA5 (0.45) | GABRA5 | |
| SCHEMBL285911 | 0.83 | GABRA5 (0.45) | GABRA5 | |
| SCHEMBL285559 | 0.83 | POLB (0.40) | LMNAKMT2APTGS2GABRA5BACE1 | |
| SCHEMBL286468 | 0.83 | POLB (0.40) | LMNAKMT2APTGS2GABRA5BACE1 | |
| SCHEMBL286118 | 0.83 | POLB (0.40) | LMNAKMT2APTGS2GABRA5BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |