Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865272 | 0.83 | DHFR (0.33) | MAPTHTT | |
| SCHEMBL2862935 | 0.76 | FYN (0.40) | — | |
| SCHEMBL2857280 | 0.75 | EGFR (0.33) | — | |
| SCHEMBL2855790 | 0.69 | MAPT (0.43) | ALDH1A1MAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL4379642 | 0.69 | EGFR (0.37) | MAPTKDM4E | |
| SCHEMBL2868679 | 0.68 | MAPT (0.40) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL4384782 | 0.67 | — | — | |
| SCHEMBL4387756 | 0.66 | ALDH1A1 (0.34) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL3579808 | 0.65 | MAPT (0.50) | TTRALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL2869133 | 0.65 | FYN (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767693-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | disclosed |