Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 11/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HBB | P68871 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.37 |
| ▸ | POLG | P54098 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434143 | 0.80 | PNP (0.57) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL2858495 | 0.78 | PNP (0.53) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL9566544 | 0.76 | PNP (0.71) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL9019935 | 0.73 | MEN1 (0.68) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL8781905 | 0.72 | PNP (0.55) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL12671989 | 0.71 | MEN1 (0.66) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL8445568 | 0.69 | MEN1 (0.73) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL31043036 | 0.68 | PNP (0.78) | PNPKMT2AMEN1HBBALDH1A1 | |
| SCHEMBL14421640 | 0.68 | PNP (0.74) | PNPKMT2AMEN1HBBMAPK1 | |
| SCHEMBL7198505 | 0.68 | PNP (0.53) | PNPKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142548-A1 | NOVEL DERIVATIVES OF PURINIC AND PYRIMIDINIC ANTIVIRAL AGENTS AND USE THEREOF AS POTENT ANTICANCER AGENTS | Ramot at Tel-Aviv University Ltd. (IL) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008120205-A1 | NOVEL DERIVATIVES OF PURINIC AND PYRIMIDINIC ANTIVIRAL AGENTS AND USE THEREOF AS POTENT ANTICANCER AGENTS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2008-10-09 | — | — | WO | disclosed |