Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 7/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 9/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857507 | 0.85 | BRAF (0.39) | BRAFKDRMAP4K4NPC1MAPT | |
| SCHEMBL2851409 | 0.84 | BRAF (0.62) | BRAFKDRRIPK3RIPK1NPC1 | |
| SCHEMBL2864471 | 0.82 | BRAF (0.37) | BRAFKDRNPC1RAB9A | |
| SCHEMBL2851381 | 0.82 | BRAF (0.77) | BRAFKDRRIPK3RIPK1PDGFRB | |
| SCHEMBL2853481 | 0.80 | EPHX2 (0.41) | BRAFNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2861313 | 0.80 | KDR (0.49) | KDRNPC1TP53MAPTHTT | |
| SCHEMBL14949680 | 0.78 | MET (0.44) | KDRMAP4K4NPC1RAB9A | |
| SCHEMBL2453158 | 0.77 | BRAF (0.42) | BRAFKDRNPC1TP53RAB9A | |
| SCHEMBL2852227 | 0.77 | KDM4E (0.52) | BRAFKDRRAB9ATEK | |
| SCHEMBL2455537 | 0.76 | BRAF (0.43) | BRAFKDRMAP4K4NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2399921-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-08-12 | — | — | EP | disclosed |
| US-8697874-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-15 | — | — | US | disclosed |
| EP-2399921-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2011-12-28 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |