Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 8/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22020717 | 0.76 | NOS3 (0.50) | KDM4ESMN1; SMN2L3MBTL1NOS3NOS1 | |
| SCHEMBL21963366 | 0.75 | ACHE (0.42) | NOS3NOS1NOS2ACHEMEN1 | |
| SCHEMBL31475657 | 0.75 | ACHE (0.42) | NOS3NOS1NOS2ACHEMEN1 | |
| SCHEMBL2624109 | 0.75 | NOS3 (0.42) | KDM4ETDP1NOS3NOS1NOS2 | |
| SCHEMBL29606582 | 0.75 | NOS3 (0.42) | KDM4ETDP1NOS3NOS1NOS2 | |
| SCHEMBL527306 | 0.72 | NOS3 (0.48) | KDM4ENOS3NOS1NOS2ACHE | |
| SCHEMBL16871986 | 0.72 | ACHE (0.42) | NOS3NOS1NOS2ACHEMEN1 | |
| SCHEMBL28068966 | 0.72 | NOS3 (0.40) | KDM4ETDP1L3MBTL1NOS3NOS1 | |
| SCHEMBL25250210 | 0.71 | ACHE (0.40) | KDM4ETDP1SMN1; SMN2L3MBTL1NOS3 | |
| SCHEMBL29606298 | 0.71 | ACHE (0.40) | KDM4ETDP1L3MBTL1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113234079-B | Nucleoside analogs as PRMT5 inhibitors | 上海湃隆生物科技有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113234079-A | Nucleoside analogs as PRMT5 inhibitors | 上海湃隆生物科技有限公司 | 2021-08-10 | — | — | CN | disclosed |