Isothiocyanate

Isothiocyanate

SCHEMBL28619475

N=C=S.NS(=O)(=O)c1cccc2ccccc12

nearest known ligand 0.79

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 7/20 0.79
CA1 P00915 7/20 0.79
CA9 Q16790 6/20 0.79
CDK2 P24941 1/20 0.50
F2 P00734 3/20 0.47
PRSS1 P07477 3/20 0.47
PRSS2 P07478 3/20 0.47
PRSS3 P35030 3/20 0.47
HTR6 P50406 1/20 0.47
LDHA P00338 1/20 0.46
ATIC P31939 1/20 0.45
HCRTR1 O43613 1/20 0.43
CA12 O43570 4/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
CA4 P22748 2/20 0.42
CA6 P23280 2/20 0.42
CYP2C9 P11712 2/20 0.42
CA5A P35218 1/20 0.42
CA7 P43166 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29529240 0.89 CA2 (1.00) CA2CA1CA9CDK2F2
SCHEMBL28464 0.89 CA2 (1.00) CA2CA1CA9CDK2F2
SCHEMBL27901054 0.87 CA2 (0.96) CA2CA1CA9CDK2F2
Ammonia Solution, Strong SCHEMBL28028391 0.87 CA2 (0.96) CA2CA1CA9CDK2F2
Hydrochloric Acid SCHEMBL951327 0.87 CA2 (0.96) CA2CA1CA9CDK2F2
Benzene SCHEMBL11062753 0.87 CA2 (0.96) CA2CA1CA9CDK2F2
Hydrochloric Acid SCHEMBL8125684 0.85 CA2 (0.92) CA2CA1CA9CDK2F2
Phosphoric Acid SCHEMBL28841729 0.80 CA2 (0.81) CA2CA1CA9CDK2F2
Acetamide SCHEMBL28617889 0.79 CA2 (0.79) CA2CA1CA9CDK2F2
SCHEMBL3149642 0.78 CA2 (0.78) CA2CA1CA9CDK2F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113264859-B Naphthalene sulfonamide isothiocyanate bifunctional micromolecules as well as preparation method and application thereof 宁夏医科大学 2023-02-07 CN claimed
CN-113264859-A Naphthalene sulfonamide isothiocyanate bifunctional micromolecules as well as preparation method and application thereof 宁夏医科大学 2021-08-17 CN claimed
CN-113264859-B Naphthalene sulfonamide isothiocyanate bifunctional micromolecules as well as preparation method and application thereof 宁夏医科大学 2023-02-07 CN disclosed
CN-113264859-B Naphthalene sulfonamide isothiocyanate bifunctional micromolecules as well as preparation method and application thereof 宁夏医科大学 2023-02-07 CN disclosed
CN-113264859-B Naphthalene sulfonamide isothiocyanate bifunctional micromolecules as well as preparation method and application thereof 宁夏医科大学 2023-02-07 CN disclosed
CN-113264859-A Naphthalene sulfonamide isothiocyanate bifunctional micromolecules as well as preparation method and application thereof 宁夏医科大学 2021-08-17 CN disclosed
CN-113264859-A Naphthalene sulfonamide isothiocyanate bifunctional micromolecules as well as preparation method and application thereof 宁夏医科大学 2021-08-17 CN disclosed