SCHEMBL28619928

SCHEMBL28619928

NC(=O)c1ccccc1C1=Cc2ccccc2SN=C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.41
CSNK1A1 P48729 1/20 0.38
TYRO3 Q06418 1/20 0.38
DYRK1B Q9Y463 1/20 0.38
TRPA1 O75762 3/20 0.37
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35
KDM4E B2RXH2 2/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
NUDT1 P36639 1/20 0.34
DPP4 P27487 1/20 0.33
GRM5 P41594 1/20 0.33
CTNNB1 P35222 1/20 0.33
METAP2 P50579 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urea SCHEMBL9162913 0.72 BCHE (0.37) BCAT2TRPA1RAB9ATSHRGPR84
Carbamic Acid SCHEMBL4912038 0.71 BCHE (0.36) BCAT2TRPA1RAB9AALDH1A1MAPT
SCHEMBL28619927 0.68 BCAT2 (0.42) BCAT2CSNK1A1TYRO3DYRK1BTRPA1
SCHEMBL210767 0.67 BCAT2 (0.74) BCAT2CSNK1A1TYRO3DYRK1BNPC1
SCHEMBL30514077 0.67 BCAT2 (0.74) BCAT2CSNK1A1TYRO3DYRK1BNPC1
SCHEMBL7849227 0.67 TRPA1 (0.33) TRPA1GPR84
SCHEMBL8555 0.66 TRPA1 (0.35) TRPA1KDM4EALDH1A1MAPTHPGD
SCHEMBL1110181 0.65 BCAT2 (0.71) BCAT2CSNK1A1TYRO3DYRK1BNPC1
SCHEMBL31012518 0.65 BCAT2 (0.71) BCAT2CSNK1A1TYRO3DYRK1BNPC1
Hydrochloric Acid SCHEMBL16463881 0.65 BCAT2 (0.71) BCAT2CSNK1A1TYRO3DYRK1BNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107889487-B Bicyclic tetrahydrothiazepine derivatives for the treatment of tumor and/or infectious diseases 阿派隆生物制剂股份公司 2021-09-03 CN disclosed