Urea

Urea

SCHEMBL9162913

C1=NSc2ccccc2-c2ccccc21.NC(N)=O

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.37
ACHE P22303 1/20 0.37
LMNA P02545 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
SCN4A P35499 1/20 0.34
SCN5A Q14524 1/20 0.34
SCN9A Q15858 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
TRPA1 O75762 2/20 0.32
HTR2B P41595 1/20 0.32
THRB P10828 1/20 0.32
RAB9A P51151 1/20 0.32
BCAT2 O15382 1/20 0.32
GPR84 Q9NQS5 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbamic Acid SCHEMBL4912038 0.95 BCHE (0.36) BCHEACHELMNATSHRMAPK1
SCHEMBL8555 0.91 TRPA1 (0.35) BCHEACHELMNAMEN1KMT2A
SCHEMBL27969577 0.78
SCHEMBL29039007 0.74 MEN1 (0.41) MEN1KMT2ATHRB
SCHEMBL28619928 0.72 BCAT2 (0.41) TSHRTRPA1RAB9ABCAT2GPR84
Urea SCHEMBL9162904 0.70 TSHR (0.37) BCHEACHELMNATSHRMAPK1
SCHEMBL20263764 0.67 MAPT (0.36) BCHEACHETSHRMEN1KMT2A
Urea SCHEMBL8887503 0.67 TRPA1 (0.40) LMNATSHRMAPK1SCN4ASCN5A
Urea SCHEMBL6255302 0.66 KMT2A (0.50) BCHELMNATSHRMAPK1MEN1
Carbamic Acid SCHEMBL4912022 0.66 LMNA (0.36) BCHEACHELMNATSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5449675-A Analgesics G. D. SEARLE & CO. (US) 1995-09-12 US disclosed