Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ATF4 | P18848 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 6/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | ACACA | Q13085 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PRLHR | P49683 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20989201 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1GAALMNAMAPT | |
| SCHEMBL19705237 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1HPGDGAAATF4 | |
| SCHEMBL4533467 | 0.79 | POLB (0.76) | SMN1; SMN2L3MBTL1HPGDATF4LMNA | |
| SCHEMBL19692581 | 0.77 | POLB (0.66) | SMN1; SMN2L3MBTL1HPGDATF4LMNA | |
| SCHEMBL12067608 | 0.76 | ALDH1A1 (0.72) | SMN1; SMN2L3MBTL1HPGDGAAATF4 | |
| SCHEMBL3918153 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2L3MBTL1HPGDGAAATF4 | |
| SCHEMBL29532316 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2L3MBTL1HPGDGAAATF4 | |
| SCHEMBL3918149 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2L3MBTL1HPGDGAAATF4 | |
| SCHEMBL27979662 | 0.75 | POLB (0.84) | SMN1; SMN2L3MBTL1HPGDGAAATF4 | |
| SCHEMBL20989310 | 0.74 | L3MBTL1 (0.50) | SMN1; SMN2L3MBTL1GAAMAPTACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563071-B | Chemical compounds as inhibitors of the ATF4pathway | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-08-03 | — | — | CN | claimed |
| CN-109563071-B | Chemical compounds as inhibitors of the ATF4pathway | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-08-03 | — | — | CN | disclosed |