Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.64 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.64 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.47 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28620196 | 1.00 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1TSHR | |
| Succinic Acid SCHEMBL1643228 | 1.00 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1TSHR | |
| Succinic Acid SCHEMBL285626 | 0.96 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1TSHR | |
| Succinic Acid SCHEMBL28408477 | 0.93 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1TSHR | |
| Succinic Acid SCHEMBL22471654 | 0.84 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1TSHR | |
| Succinic Acid SCHEMBL2583036 | 0.84 | — | — | |
| Succinic Acid SCHEMBL14881109 | 0.84 | OR51E2 (0.59) | LMNAEGLN1ALKBH5SUCNR1TSHR | |
| Succinic Acid SCHEMBL3039741 | 0.83 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1TSHR | |
| Adipic Acid SCHEMBL4637028 | 0.83 | LMNA (0.73) | LMNATSHRMEN1BLMKMT2A | |
| Alpha-Ketoglutaric Acid SCHEMBL28457662 | 0.82 | EGLN1 (0.78) | LMNAEGLN1ALKBH5SUCNR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113304122-B | Ts antibacterial peptide-TPGS modified composite nano drug delivery system and preparation and application thereof | 浙江大学 | 2022-05-10 | — | — | CN | claimed |
| CN-113304122-A | Ts antibacterial peptide-TPGS modified composite nano drug delivery system and preparation and application thereof | 浙江大学 | 2021-08-27 | — | — | CN | claimed |
| CN-113304122-B | Ts antibacterial peptide-TPGS modified composite nano drug delivery system and preparation and application thereof | 浙江大学 | 2022-05-10 | — | — | CN | disclosed |
| CN-113304122-A | Ts antibacterial peptide-TPGS modified composite nano drug delivery system and preparation and application thereof | 浙江大学 | 2021-08-27 | — | — | CN | disclosed |