Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28619301 | 1.00 | TGM2 (0.61) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28617576 | 0.88 | TGM2 (0.66) | TGM2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL28615912 | 0.87 | TGM2 (0.61) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28624100 | 0.87 | B3GNT2 (0.47) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28627367 | 0.87 | TGM2 (0.47) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28630813 | 0.87 | KMT2A (0.60) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28619644 | 0.87 | KMT2A (0.60) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28617369 | 0.87 | KMT2A (0.60) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28616230 | 0.85 | NPC1 (0.52) | TGM2NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL28615353 | 0.85 | TGM2 (0.66) | TGM2NPC1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109438279-B | Small molecule compound for overcoming EGFR drug-resistant mutation and preparation method and application thereof | 四川大学 | 2021-08-31 | — | — | CN | disclosed |