SCHEMBL28622150

SCHEMBL28622150

O=C(O)c1c(Cl)c(Cl)c(C(=O)OCl)c(Cl)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HSD17B10 Q99714 1/20 0.33
DPP4 P27487 1/20 0.33
HTT P42858 1/20 0.33
CES2 O00748 1/20 0.30
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5849902 0.88 HTT (0.40) KDM4EALDH1A1HSD17B10DPP4HTT
SCHEMBL4364573 0.82 DPP4 (0.34) KDM4EALDH1A1HSD17B10DPP4HTT
SCHEMBL8564289 0.81 CES2 (0.33) CES2CES1
SCHEMBL990565 0.81 CES2 (0.39) CES2CES1
SCHEMBL28410963 0.81 CYP1A2 (0.33) KDM4EALDH1A1HSD17B10DPP4
SCHEMBL4899263 0.81 DPP4 (0.43) KDM4EALDH1A1HSD17B10DPP4HTT
SCHEMBL70425 0.81 DPP4 (0.43) KDM4EALDH1A1HSD17B10DPP4HTT
Succinic Acid SCHEMBL27535104 0.79 EGLN1 (0.39) KDM4ECES2CES1
Dacthal SCHEMBL8539721 0.78 CA12 (0.41) KDM4EALDH1A1HSD17B10HTT
SCHEMBL162169 0.78 CA12 (0.41) KDM4EALDH1A1HSD17B10HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110997838-B Silicone-polyether copolymers, sealants including silicone-polyether copolymers, and related methods 美国陶氏有机硅公司 2021-10-01 CN disclosed
CN-110997839-B Silicone-polyether copolymer, method of preparing silicone-polyether copolymer, and sealant including silicone-polyether copolymer 美国陶氏有机硅公司 2021-09-14 CN disclosed
CN-110997840-B Silicone-polyether copolymers, isocyanate-functionalized silicone-polyether copolymers formed therewith, silicone-polyether-urethane copolymers, sealants including the same, and related methods 美国陶氏有机硅公司 2021-09-07 CN disclosed