Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 7/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26668984 | 0.75 | SLC5A2 (0.33) | — | |
| SCHEMBL8004673 | 0.75 | HTR4 (0.40) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8686728 | 0.75 | HTR4 (0.40) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8509459 | 0.74 | HTR4 (0.52) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5042500 | 0.73 | HTR4 (0.51) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL1502018 | 0.73 | HTR4 (0.51) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL14810412 | 0.73 | HTR4 (0.59) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL28922401 | 0.73 | ACVRL1 (0.36) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5035685 | 0.72 | HTR4 (0.41) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL28520659 | 0.71 | HTR4 (0.39) | HTR4HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232544-B | Preparation method of prucalopride | 江苏工程职业技术学院 | 2021-09-14 | — | — | CN | claimed |
| CN-114539133-B | Method for preparing prucalopride intermediate 1- (3-methoxypropyl) -4-piperidinamine | 鲁南制药集团股份有限公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-117050003-A | Preparation method of 1- (3-methoxypropyl) -4-piperidinamine | 山东新时代药业有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-115703733-A | Preparation method of prucalopride intermediate | 山东新时代药业有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-115197123-A | Preparation method of prucalopride intermediate 1- (3-methoxypropyl) -4-piperidinamine | 山东新时代药业有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-114591278-A | Preparation method of 4-acetamido-5-chloro-2, 3-dihydrobenzofuran-7-carboxylic acid methyl ester | 鲁南制药集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-114591220-A | Preparation method of prucalopride intermediate 1- (3-methoxypropyl) -4-piperidinamine | 鲁南制药集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-114539134-A | Synthetic method of prucalopride intermediate 1- (3-methoxypropyl) -4-piperidinamine | 鲁南制药集团股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-114539133-A | Method for preparing prucalopride intermediate 1- (3-methoxypropyl) -4-piperidinamine | 鲁南制药集团股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-109232544-B | Preparation method of prucalopride | 江苏工程职业技术学院 | 2021-09-14 | — | — | CN | disclosed |