Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | APLNR | P35414 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23201898 | 0.89 | APLNR (0.51) | ALDH1A1POLBHTR2AAPLNRDPP7 | |
| SCHEMBL23201900 | 0.89 | APLNR (0.51) | ALDH1A1POLBHTR2AAPLNRDPP7 | |
| SCHEMBL491054 | 0.86 | ALDH1A1 (0.51) | ALDH1A1POLBTDP1TSHRMAPK1 | |
| SCHEMBL29519833 | 0.84 | HSD17B10 (0.49) | ALDH1A1POLBTDP1HTR2AAPLNR | |
| Hydrochloric Acid SCHEMBL8862614 | 0.83 | HSD17B10 (0.48) | HTR2AAPLNRDPP7MEN1KMT2A | |
| SCHEMBL20543840 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBSCN9ATSHRMEN1 | |
| SCHEMBL26985715 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBSCN9ATSHRMEN1 | |
| SCHEMBL6301729 | 0.80 | SCN9A (0.60) | SCN9AHTR2AMEN1KMT2AMAPT | |
| SCHEMBL21384322 | 0.80 | SCN9A (0.60) | SCN9AHTR2AMEN1KMT2AMAPT | |
| SCHEMBL17500269 | 0.80 | SCN9A (0.69) | ALDH1A1TDP1SCN9ATSHRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485276-B | Deuterated AKT kinase inhibitors | 南京正大天晴制药有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117964620-A | AKT inhibitors | 南京正大天晴制药有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-113272304-B | AKT inhibitors | 南京正大天晴制药有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115485276-A | Deuterated AKT kinase inhibitors | 南京正大天晴制药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-113272304-A | AKT inhibitors | 南京正大天晴制药有限公司 | 2021-08-17 | — | — | CN | disclosed |