Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730391 | 0.83 | SIGMAR1 (0.57) | THRBSIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL12394322 | 0.83 | SIGMAR1 (0.55) | MEN1KMT2ASIGMAR1HRH3MBTD1 | |
| SCHEMBL13595130 | 0.83 | MEN1 (0.70) | MEN1KMT2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL10256869 | 0.82 | SLC6A3 (0.63) | MEN1KMT2ASIGMAR1KCNH2CYP3A4 | |
| SCHEMBL1427500 | 0.82 | KMT2A (0.69) | MEN1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL1239240 | 0.80 | SIGMAR1 (0.57) | THRBSIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL1241103 | 0.80 | HRH3 (0.68) | SIGMAR1HRH3MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL4960414 | 0.80 | HRH3 (0.62) | SIGMAR1HRH3MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL13595098 | 0.79 | MEN1 (0.47) | MEN1KMT2ASIGMAR1HRH3MBTD1 | |
| SCHEMBL6627983 | 0.78 | HRH3 (0.71) | SIGMAR1HRH3MBTD1L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108341814-B | JAK kinase inhibitors and uses thereof | 上海翔锦生物科技有限公司 | 2021-09-03 | — | — | CN | disclosed |