SCHEMBL28623336

SCHEMBL28623336

O=C(O)C1=CC=CC(Cl)(Cl)C1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
THRB P10828 1/20 0.36
BLM P54132 1/20 0.36
PMP22 Q01453 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1236079 0.80 TSHR (0.35) TSHRMAPK1HSD17B10TDP1THRB
SCHEMBL3630326 0.80 TSHR (0.39) TSHRMAPK1HSD17B10TDP1THRB
Hydrochloric Acid SCHEMBL17667156 0.79 THRB (0.37) TSHRMAPK1HSD17B10TDP1THRB
SCHEMBL14059434 0.79
Hydrochloric Acid SCHEMBL1965355 0.79 THRB (0.37) TSHRMAPK1HSD17B10TDP1THRB
SCHEMBL3961385 0.77 TSHR (0.38) TSHRMAPK1HSD17B10TDP1THRB
SCHEMBL28621880 0.75 TSHR (0.41) TSHRMAPK1HSD17B10TDP1THRB
SCHEMBL8210522 0.75 TSHR (0.37) TSHRMAPK1HSD17B10TDP1THRB
SCHEMBL9161010 0.73 TSHR (0.40) TSHRMAPK1HSD17B10TDP1THRB
SCHEMBL466286 0.73 TSHR (0.36) TSHRMAPK1HSD17B10TDP1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113402411-B Oxidation reaction-based synthesis method of propyzamide 深圳市谦陌通辰实验有限公司 2022-11-29 CN disclosed
CN-113402411-A Oxidation reaction-based synthesis method of propyzamide 深圳市谦陌通辰实验有限公司 2021-09-17 CN disclosed