Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | FABP7 | O15540 | 2/20 | 0.37 |
| ▸ | FABP3 | P05413 | 2/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL28609219 | 0.99 | KDM4E (0.44) | KDM4EELANEALOX15FABP7FABP3 | |
| Naphthylamine SCHEMBL29101487 | 0.78 | ALDH1A1 (0.46) | ELANEALOX15ALDH1A1HSD17B10CYP3A4 | |
| Naphthylamine SCHEMBL27804357 | 0.77 | ALDH1A1 (0.47) | ELANEALOX15ALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL4614497 | 0.76 | AAK1 (0.50) | KDM4ECYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL9643299 | 0.76 | AAK1 (0.50) | KDM4ECYP1A2CYP2D6CYP2C19CYP3A4 | |
| Hydrochloric Acid SCHEMBL7267342 | 0.76 | KDM4E (0.47) | KDM4ECYP1A2RAB9ACYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL22445135 | 0.76 | EP300 (0.48) | KDM4EALOX15ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL11121066 | 0.75 | KDM4E (0.47) | KDM4ECYP1A2RAB9ACYP2D6CYP2C19 | |
| Proline SCHEMBL18438885 | 0.74 | ALDH1A1 (0.47) | KDM4EELANEALDH1A1NPC1RAB9A | |
| Proline SCHEMBL18438884 | 0.74 | ALDH1A1 (0.47) | KDM4EELANEALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107779494-B | Kit for detecting infectious vaginitis and preparation method thereof | 北京中生金域诊断技术股份有限公司 | 2021-08-17 | — | — | CN | claimed |
| CN-107779494-B | Kit for detecting infectious vaginitis and preparation method thereof | 北京中生金域诊断技术股份有限公司 | 2021-08-17 | — | — | CN | disclosed |