Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naphthylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthylamine SCHEMBL27804357 | 0.99 | ALDH1A1 (0.47) | ALDH1A1CYP3A4HSD17B10ALOX15CASP1 | |
| Proline SCHEMBL29225523 | 0.84 | SLC6A4 (0.44) | ELANESLC6A4SLC6A2SLC6A3 | |
| Proline SCHEMBL28623387 | 0.78 | KDM4E (0.43) | ALDH1A1CYP3A4HSD17B10ALOX15ELANE | |
| Proline SCHEMBL28609219 | 0.77 | KDM4E (0.44) | ALDH1A1CYP3A4HSD17B10ALOX15ELANE | |
| Proline SCHEMBL18438885 | 0.77 | ALDH1A1 (0.47) | ALDH1A1CYP3A4HSD17B10ELANEDPP4 | |
| Proline SCHEMBL18438884 | 0.77 | ALDH1A1 (0.47) | ALDH1A1CYP3A4HSD17B10ELANEDPP4 | |
| Biphenyl SCHEMBL2308811 | 0.76 | ELANE (0.47) | CYP3A4ELANEDPP4ANPEPHTR2C | |
| Proline SCHEMBL16394427 | 0.75 | BLM (0.48) | ALOX15ELANEDPP4DPP8 | |
| Questiomycin B SCHEMBL27740312 | 0.74 | ALOX15 (0.46) | CYP3A4ALOX15ELANEDPP4ANPEP | |
| SCHEMBL28323068 | 0.74 | SLC6A4 (0.50) | ALDH1A1ELANESLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117265066-A | Colpitis multi-joint inspection kit | 郑州安图生物工程股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117004685-A | Colpitis multi-joint inspection kit | 郑州安图生物工程股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-116179646-A | Colpitis multi-joint inspection kit | 郑州安图生物工程股份有限公司 | 2023-05-30 | — | — | CN | disclosed |