Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.65 |
| ▸ | RELA | Q04206 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29643961 | 1.00 | MAPT (0.65) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28620094 | 0.89 | NPC1 (0.69) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL29643911 | 0.89 | NPC1 (0.69) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL29644052 | 0.86 | GRM4 (0.59) | NPC1RAB9AKDRGRM4KMT2A | |
| SCHEMBL28628481 | 0.86 | GRM4 (0.59) | NPC1RAB9AKDRGRM4KMT2A | |
| SCHEMBL31087264 | 0.84 | HDAC6 (0.62) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28611795 | 0.84 | HDAC6 (0.62) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1536653 | 0.83 | RAB9A (0.65) | MAPTNPC1RAB9AHTTGRM4 | |
| SCHEMBL29644059 | 0.78 | GRM4 (0.59) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28625315 | 0.78 | GRM4 (0.59) | MAPTNPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113278007-B | Synthetic method of 2-hydroxy-indole-3-ketone compound | 延安大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-113278007-A | Synthetic method of 2-hydroxy-indole-3-ketone compound | 延安大学 | 2021-08-20 | — | — | CN | disclosed |