Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 6/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644052 | 1.00 | GRM4 (0.59) | GRM4HDAC6KDRGRIK1KMT2A | |
| SCHEMBL28625315 | 0.89 | GRM4 (0.59) | GRM4HDAC6KDRKMT2AGRM5 | |
| SCHEMBL29644059 | 0.89 | GRM4 (0.59) | GRM4HDAC6KDRKMT2AGRM5 | |
| SCHEMBL1307746 | 0.87 | GRIK1 (0.70) | GRM4HDAC6GRIK1KMT2AGRM5 | |
| SCHEMBL29643961 | 0.86 | MAPT (0.65) | GRM4HDAC6KDRKMT2AHDAC3 | |
| SCHEMBL28623966 | 0.86 | MAPT (0.65) | GRM4HDAC6KDRKMT2AHDAC3 | |
| SCHEMBL28611795 | 0.84 | HDAC6 (0.62) | GRM4HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL31087264 | 0.84 | HDAC6 (0.62) | GRM4HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL1536653 | 0.83 | RAB9A (0.65) | GRM4HDAC6KMT2AGRM5NPC1 | |
| SCHEMBL29217385 | 0.82 | GRM4 (0.61) | GRM4HDAC6KDRKMT2AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113278007-B | Synthetic method of 2-hydroxy-indole-3-ketone compound | 延安大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-113278007-A | Synthetic method of 2-hydroxy-indole-3-ketone compound | 延安大学 | 2021-08-20 | — | — | CN | disclosed |