Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methoxyamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxymethane SCHEMBL11145545 | 0.91 | GAA (0.54) | ALDH1A1CA1CA2TSHRCA12 | |
| Methoxymethane SCHEMBL3404680 | 0.91 | GAA (0.54) | ALDH1A1CA1CA2TSHRCA12 | |
| Methylamine SCHEMBL4135110 | 0.89 | ALDH1A1 (0.58) | ALDH1A1CA1CA2TSHRCA12 | |
| Hydrazine SCHEMBL8861759 | 0.89 | ALDH1A1 (0.58) | ALDH1A1CA1CA2TSHRCA12 | |
| Hydroxyamine SCHEMBL599912 | 0.89 | ALDH1A1 (0.58) | ALDH1A1CA1CA2TSHRCA12 | |
| P-Xylene SCHEMBL8660591 | 0.89 | GAA (0.62) | ALDH1A1CA1CA2TSHRCA12 | |
| SCHEMBL1705904 | 0.89 | GAA (0.62) | ALDH1A1CA1CA2TSHRCA12 | |
| SCHEMBL5068661 | 0.89 | GAA (0.62) | ALDH1A1CA1CA2TSHRCA12 | |
| SCHEMBL34 | 0.89 | GAA (0.62) | ALDH1A1CA1CA2TSHRCA12 | |
| SCHEMBL31313 | 0.89 | GAA (0.62) | ALDH1A1CA1CA2TSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113372363-B | Preparation method of descarbamoyl cefuroxime | 广东立国制药有限公司 | 2022-11-25 | — | — | CN | claimed |
| CN-113372363-A | Preparation method of descarbamoyl cefuroxime | 深圳市立国药物研究有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-113372363-B | Preparation method of descarbamoyl cefuroxime | 广东立国制药有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-113372363-A | Preparation method of descarbamoyl cefuroxime | 深圳市立国药物研究有限公司 | 2021-09-10 | — | — | CN | disclosed |