Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286422 | 0.95 | GABRA5 (0.64) | GABRA5HCAR3 | |
| SCHEMBL285717 | 0.85 | HCAR3 (0.56) | GABRA5HCAR3 | |
| SCHEMBL285474 | 0.83 | GABRA5 (0.66) | GABRA5 | |
| SCHEMBL285422 | 0.79 | GABRA5 (0.55) | GABRA5 | |
| SCHEMBL108484 | 0.78 | GABRA5 (0.63) | GABRA5 | |
| SCHEMBL285420 | 0.76 | GABRA5 (0.69) | GABRA5 | |
| SCHEMBL285746 | 0.75 | GABRA5 (0.62) | GABRA5 | |
| SCHEMBL2926167 | 0.74 | GABRA5 (1.00) | GABRA5 | |
| SCHEMBL195457 | 0.73 | GABRA5 (0.41) | GABRA5 | |
| SCHEMBL195458 | 0.73 | GABRA5 (0.41) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427457-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127978-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |