Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DHPS | P49366 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28777046 | 0.88 | ALDH1A1 (0.41) | MAPK14ALDH1A1MAPTPTGS2KMT2A | |
| SCHEMBL15674260 | 0.65 | SYK (0.48) | MAPK14ALDH1A1TP53GAAKMT2A | |
| SCHEMBL25364247 | 0.65 | KMT2A (0.47) | MAPK14ALDH1A1MAPTGAAPTGS2 | |
| SCHEMBL29947623 | 0.64 | GAA (0.40) | ALDH1A1HSD17B10MAPTGAAKMT2A | |
| SCHEMBL6598145 | 0.63 | MAPK14 (0.63) | MAPK14HSD17B10TP53PTGS2KMT2A | |
| SCHEMBL5379814 | 0.62 | MAPK14 (0.61) | MAPK14ALDH1A1POLBMAPTGAA | |
| SCHEMBL7506245 | 0.61 | KDM4E (0.36) | ALDH1A1POLBHSD17B10MAPTTP53 | |
| SCHEMBL1853624 | 0.61 | JAK2 (0.50) | ALDH1A1MAPTKMT2ASMN1; SMN2JAK2 | |
| SCHEMBL2251839 | 0.61 | JAK2 (0.50) | JAK2PDE10A | |
| SCHEMBL5288600 | 0.60 | SLC6A4 (0.51) | MAPK14ALDH1A1PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113387947-B | Pyrazolopyridine derivatives that modulate estrogen receptor synthesis activity | 中国科学院成都生物研究所 | 2022-07-01 | — | — | CN | disclosed |
| CN-113387947-A | Pyrazolopyridine derivatives that modulate estrogen receptor synthesis activity | 中国科学院成都生物研究所 | 2021-09-14 | — | — | CN | disclosed |