Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 8/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29172445 | 0.86 | L3MBTL1 (0.36) | L3MBTL1HTTPOLBALDH3A1NOD1 | |
| SCHEMBL26638302 | 0.86 | L3MBTL1 (0.36) | L3MBTL1HTTPOLBALDH3A1NOD1 | |
| SCHEMBL26638303 | 0.84 | L3MBTL1 (0.38) | L3MBTL1HTTPOLBALDH3A1NOD1 | |
| SCHEMBL30798109 | 0.84 | JAK1 (0.39) | L3MBTL1HTTPOLBALDH3A1NOD1 | |
| SCHEMBL26638292 | 0.84 | JAK1 (0.39) | L3MBTL1HTTPOLBALDH3A1NOD1 | |
| SCHEMBL26638298 | 0.83 | L3MBTL1 (0.38) | L3MBTL1HTTPOLBALDH3A1NOD1 | |
| SCHEMBL26638305 | 0.83 | L3MBTL1 (0.37) | L3MBTL1HTTPOLBALDH3A1NOD1 | |
| SCHEMBL28621769 | 0.80 | JAK1 (0.52) | L3MBTL1POLBJAK1JAK2TYK2 | |
| SCHEMBL28634235 | 0.80 | JAK1 (0.52) | L3MBTL1POLBJAK1JAK2TYK2 | |
| SCHEMBL30622213 | 0.80 | JAK1 (0.52) | L3MBTL1POLBJAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396150-A | Tricyclic JANUS kinase 1 inhibitors, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2021-09-14 | — | — | CN | disclosed |