Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28637033 | 1.00 | L3MBTL1 (0.36) | L3MBTL1HTR6CCR6CYP3A4DRD2 | |
| SCHEMBL28634279 | 0.88 | L3MBTL1 (0.34) | L3MBTL1HTR6CCR6CYP3A4DRD2 | |
| SCHEMBL26638293 | 0.87 | L3MBTL1 (0.38) | L3MBTL1HTR6CCR6PKMALDH1A1 | |
| SCHEMBL29172444 | 0.87 | L3MBTL1 (0.38) | L3MBTL1HTR6CCR6PKMALDH1A1 | |
| SCHEMBL28637052 | 0.87 | L3MBTL1 (0.39) | L3MBTL1HTR6CCR6CYP3A4PTPN11 | |
| SCHEMBL30051724 | 0.85 | L3MBTL1 (0.36) | L3MBTL1HTR6CCR6CYP3A4ALDH1A1 | |
| SCHEMBL28830396 | 0.85 | L3MBTL1 (0.36) | L3MBTL1HTR6CCR6CYP3A4ALDH1A1 | |
| SCHEMBL28830509 | 0.83 | L3MBTL1 (0.35) | L3MBTL1HTR6CCR6CYP3A4ALDH1A1 | |
| SCHEMBL30052320 | 0.83 | L3MBTL1 (0.35) | L3MBTL1HTR6CCR6CYP3A4ALDH1A1 | |
| SCHEMBL28830431 | 0.83 | L3MBTL1 (0.35) | L3MBTL1HTR6CCR6CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396150-B | Tricyclic JANUS kinase 1 inhibitors and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-113396150-A | Tricyclic JANUS kinase 1 inhibitors, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2021-09-14 | — | — | CN | disclosed |