Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 3/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29871026 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1MAPTHSD17B10MPL | |
| SCHEMBL8269433 | 0.71 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTHSD17B10TLR4 | |
| SCHEMBL30487367 | 0.67 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTHSD17B10TLR4 | |
| SCHEMBL5679546 | 0.66 | SCN4A (0.54) | KDM4EALDH1A1MAPTHSD17B10MPL | |
| SCHEMBL20043179 | 0.66 | GRM4 (0.34) | — | |
| SCHEMBL15850523 | 0.65 | KIF11 (0.44) | MPLKIF11 | |
| SCHEMBL29746135 | 0.64 | KIF11 (0.47) | ALDH1A1MPLKIF11 | |
| SCHEMBL437730 | 0.64 | KIF11 (0.47) | ALDH1A1MPLKIF11 | |
| SCHEMBL1588990 | 0.62 | KIF11 (0.45) | ALDH1A1MPLKIF11 | |
| SCHEMBL31069948 | 0.62 | KIF11 (0.45) | ALDH1A1MPLKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |