Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.34 |
| ▸ | GALR3 | O60755 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL7038290 | 0.83 | ALDH1A1 (0.56) | TSHRALDH1A1TDP1HSD17B10SMN1; SMN2 | |
| Propylene Glycol SCHEMBL24226 | 0.83 | ALDH1A1 (0.56) | TSHRALDH1A1TDP1HSD17B10CHRM2 | |
| Propylene Glycol SCHEMBL2538043 | 0.82 | — | — | |
| Propylene Glycol SCHEMBL14685915 | 0.81 | ALDH1A1 (0.53) | TSHRALDH1A1TDP1HSD17B10CHRM2 | |
| Propylene Glycol SCHEMBL5797912 | 0.80 | TSHR (0.44) | TSHRALDH1A1TDP1HSD17B10SMN1; SMN2 | |
| Propylene Glycol SCHEMBL3316533 | 0.80 | TDP1 (0.59) | TSHRALDH1A1TDP1OR51E2LMNA | |
| Propylene Glycol SCHEMBL5804824 | 0.80 | TDP1 (0.59) | TSHRALDH1A1TDP1OR51E2TP53 | |
| Butanedione SCHEMBL15009665 | 0.79 | TDP1 (0.67) | TSHRALDH1A1TDP1OR51E2LMNA | |
| Propylene Glycol SCHEMBL8850998 | 0.79 | TDP1 (0.67) | TSHRALDH1A1TDP1OR51E2TP53 | |
| Propylene Glycol SCHEMBL36041 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113438992-A | Isocyanate-free adhesives | 隆萨解决方案股份公司 | 2021-09-24 | — | — | CN | disclosed |