Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 15/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29929741 | 1.00 | MAP4K1 (0.51) | MAP4K1RETTNKSTDO2ATR | |
| SCHEMBL29930411 | 0.78 | MAP4K1 (0.49) | MAP4K1RETTNKSTDO2 | |
| SCHEMBL28927880 | 0.78 | MAP4K1 (0.49) | MAP4K1RETTNKSTDO2 | |
| SCHEMBL28927864 | 0.77 | PIM1 (0.43) | MAP4K1RET | |
| SCHEMBL29929921 | 0.77 | TDO2 (0.44) | MAP4K1TNKSTDO2ATR | |
| SCHEMBL28642686 | 0.77 | TDO2 (0.44) | MAP4K1TNKSTDO2ATR | |
| SCHEMBL28645594 | 0.75 | TNKS (0.42) | MAP4K1TNKSTDO2ATR | |
| SCHEMBL28633555 | 0.75 | MAP4K1 (0.42) | MAP4K1 | |
| SCHEMBL28927866 | 0.74 | MAP4K1 (0.46) | MAP4K1RET | |
| SCHEMBL19949883 | 0.72 | MAP4K1 (0.46) | MAP4K1RETTNKSTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-113336747-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2021-09-03 | — | — | CN | disclosed |