Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28925081 | 0.79 | MAP4K1 (0.43) | MAP4K1EGLN2MAP4K4KDM1ABACE1 | |
| SCHEMBL28631971 | 0.75 | MAP4K1 (0.51) | MAP4K1 | |
| SCHEMBL29929741 | 0.75 | MAP4K1 (0.51) | MAP4K1 | |
| SCHEMBL28638645 | 0.74 | MAP4K3 (0.39) | MAP4K1KDM1ARORC | |
| SCHEMBL28927866 | 0.74 | MAP4K1 (0.46) | MAP4K1 | |
| SCHEMBL28635707 | 0.71 | MAP4K1 (0.43) | MAP4K1EGLN2KDM1ACYP11B2 | |
| SCHEMBL28631402 | 0.69 | MAP4K1 (0.49) | MAP4K1HTTCYP11B1CYP11B2 | |
| SCHEMBL29930315 | 0.69 | MAP4K1 (0.49) | MAP4K1HTTCYP11B1CYP11B2 | |
| SCHEMBL23962778 | 0.69 | MAP4K1 (0.41) | MAP4K1EGLN2KDM1A | |
| SCHEMBL23301055 | 0.68 | ALOX5AP (0.40) | MAP4K1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-113336747-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2021-09-03 | — | — | CN | disclosed |