Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 14/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927866 | 0.87 | MAP4K1 (0.46) | PIM1MAP4K1RETTAAR1 | |
| SCHEMBL28927858 | 0.83 | RET (0.43) | MAP4K1RET | |
| SCHEMBL29930465 | 0.82 | PIM1 (0.41) | PIM1MAP4K1PIM3PIM2 | |
| SCHEMBL28927874 | 0.82 | PIM1 (0.41) | PIM1MAP4K1PIM3PIM2 | |
| SCHEMBL28631971 | 0.77 | MAP4K1 (0.51) | MAP4K1RET | |
| SCHEMBL29929741 | 0.77 | MAP4K1 (0.51) | MAP4K1RET | |
| SCHEMBL28927885 | 0.75 | MAP4K3 (0.43) | MAP4K1 | |
| SCHEMBL28634046 | 0.75 | MAP4K3 (0.59) | — | |
| SCHEMBL28638645 | 0.75 | MAP4K3 (0.39) | PIM1MAP4K1PIM3PIM2 | |
| SCHEMBL28633555 | 0.74 | MAP4K1 (0.42) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |