SCHEMBL28633006

SCHEMBL28633006

O=C(O)c1ccc2ccccc2c1-c1c(C(=O)N(C2CCCCC2)C2CCCCC2)ccc2ccccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 1/20 0.60
LDHA P00338 1/20 0.44
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
SLC6A4 P31645 6/20 0.42
SOS1 Q07889 1/20 0.42
SLC6A2 P23975 5/20 0.42
SLC6A3 Q01959 4/20 0.42
S1PR1 P21453 1/20 0.41
S1PR3 Q99500 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
HIF1A Q16665 1/20 0.41
HSD17B10 Q99714 1/20 0.41
KCNH2 Q12809 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22471663 0.85 WDR5 (0.46) WDR5LDHALMNAMAPTHTT
SCHEMBL5368713 0.79 SLC6A4 (0.42) LMNAMAPTHTTNPSR1SLC6A4
SCHEMBL21886445 0.78 SLC6A2 (0.52) LMNAMAPTHTTNPSR1SLC6A4
SCHEMBL895573 0.78 WDR5 (1.00) WDR5LDHALMNASOS1ALDH1A1
SCHEMBL29721418 0.78 WDR5 (1.00) WDR5LDHALMNASOS1ALDH1A1
SCHEMBL17042187 0.76 SLC6A4 (0.42) LMNAMAPTHTTNPSR1SLC6A4
SCHEMBL6410755 0.76 KDM2B (0.43) WDR5LMNAMAPTHTTNPSR1
SCHEMBL28623995 0.75 WDR5 (0.68) WDR5LDHALMNAMAPTSOS1
SCHEMBL28922355 0.75 WDR5 (0.68) WDR5LDHALMNASOS1ALDH1A1
SCHEMBL9812817 0.75 SLC6A2 (0.57) LMNAMAPTHTTNPSR1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113200884-B Chiral carboxylic acid compound and synthesis method and application thereof 浙江大学 2022-07-22 CN disclosed
CN-113200884-A Chiral carboxylic acid compound and synthesis method and application thereof 浙江大学 2021-08-03 CN disclosed